Each year, about half of men over age 50 receive a PSA (prostate specific antigen) screening, according to the Centers for Disease Control. PSA is a protein produced in the prostate, and high levels of PSA may indicate cancer. About 10 percent of men tested receive results that indicate elevated levels of PSA. Often, when elevated PSA levels are detected, your physician will recommend a biopsy. The good news is, nearly three quarters of those biopsies will show no cancer.